Profil Pasien COVID-19 dengan Gangguan Penghidu di RSUP Dr. M. Djamil Padang Periode 1 Januari - 31 Desember 2021

Authors

  • Rifqoh Khotimah Universitas Andalas
  • Sukri Rahman Dept THT-KL FK UNAND
  • Tofrizal Tofrizal

DOI:

https://doi.org/10.25077/jokli.v2i1.40

Keywords:

COVID-19, gangguan penghidu, D-dimer, komorbiditas, Hasil rawatan.

Abstract

Pendahuluan: Coronavirus disease 2019 atau COVID-19 merupakan wabah penyakit yang mudah menular dan menimbulkan beragam gejala. Gejala tersebut termasuk gangguan penghidu yaitu perubahan dalam kemampuan penghidu yang baru-baru ini dirasakan pasien COVID-19 dan dijadikan salah satu gejala COVID-19 yang patut diwaspadai oleh Centers for Disease Control and Prevention (CDC). Penelitian ini bertujuan untuk mengetahui profil pasien COVID-19 dengan gangguan penghidu di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif retrospektif dengan jumlah sampel 73 pasien terkonfirmasi COVID-19 yang dirawat inap. Penelitian dilakukan di Instalasi Rekam Medis RSUP Dr. M. Djamil Padang pada bulan Juli – Oktober 2022. Data diambil dari rekam medis dengan metode simple random sampling. Hasil: Hasil penelitian ini didapatkan bahwa gangguan penghidu (58,9%) banyak terjadi pada pasien COVID-19. Rentang usia >65 tahun (23,3%) merupakan usia terbanyak dan lebih banyak dialami oleh perempuan (46,5%). Hasil D-dimer yang didapatkan mengalami peningkatan yang tinggi (74,4%) dan pasien banyak yang tidak memiliki komorbiditas (55,8%). Hasil rawatan (outcome) terbanyak yakni sembuh atau perbaikan (76,7%). Kesimpulan: Dari penelitian ini dapat disimpulkan bahwa pasien COVID-19 banyak yang mengalami gangguan penghidu dengan rentang usia >65 tahun. Proporsi jenis kelamin antara perempuan dan laki-laki tidak jauh berbeda. pasien merupakan perempuan. Kadar D-dimer ditemukan mengalami peningkatan dan banyak pasien yang tidak memiliki komorbiditas serta hasil rawatan terbanyak adalah pasien yang sembuh atau perbaikan.

References

Dos Santos WG. Natural history of COVID-19 and current knowledge on treatment therapeutic options. Biomed Pharmacother. 2020;129.

Li H, Liu SM, Yu XH, Tang SL, Tang CK. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020;55(5):1.

Megawati Kiay, Olivia C.P Pelealu SKM. Anosmia pada Coronavirus disease 2019 (Covid-19). J Biomedik. 2021;13(2):168.

Moein ST, Hashemian SMR, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. IFAR. 2020;10(8):945–9.

Farasani A. Biochemical role of serum ferratin and d-dimer parameters in COVID 19 diagnosis. Saudi J Biol Sci. 2021;28(12):7488–9.

Vaira LA, De Vito A, Deiana G, Pes C, Giovanditto F, Fiore V, et al. Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation? J Laryngol Otol. 2021;135(8):723–8.

Fang X, Li S, Yu H, Wang P, Zhang Y, Chen Z, et al. Epidemiological, comorbidity factors with severity and prognosis. Aging (Albany NY). 2020;12(13):12498–500.

Jalessi M, Barati M, Rohani M, Amini E, Ourang A, Azad Z, et al. Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19. Neurol Sci. 2020;41(9):2333–6.

Mastrangelo A, Bonato M, Cinque P. Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes. Neurosci Lett. 2021;748:1–3.

Fortunato F, Martinelli D, Iannelli G, Milazzo M, Farina U, Di Matteo G, et al. Self-reported olfactory and gustatory dysfunctions in COVID-19 patients: a 1-year follow-up study in Foggia district, Italy. BMC Infect Dis. 2022;22(77):2.

Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. ’Eur Arch Oto-Rhino-Laryngol. 2020;277(8):2253–5.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683–90.

Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol - Head Neck Surg (United States). 2020;163(1):3–11.

Dan X, Wechter N, Gray S, Mohanty JG, Croteau DL, Bohr VA. Olfactory dysfunction in aging and neurodegenerative diseases. Ageing Res Rev. 2021;70:1–2.

Mesquita R, Carlos L, Silva F, Fernanda J, Santos M, Farias T, et al. Clinical manifestations of COVID-19 in the general population?: systematic review. Wien Klin Wochenschr. 2021;133(7–8):377–81.

Saussez S, Lechien JR, Hopkins C. Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered. Eur Arch Oto-Rhino-Laryngol. 2021;278(7):2187–91.

Meini S, Suardi LR, Busoni M, Roberts AT, Fortini A. Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. Eur Arch Oto-Rhino-Laryngol. 2020;277(12):3520–1.

Castillo-López IY, Govea-Camacho LH, Rodríguez-Torres IA, Recio-Macías DA, Alobid I, Mullol J. Olfactory Dysfunction in a Mexican Population Outside of COVID-19 Pandemic: Prevalence and Associated Factors (the OLFAMEX Study). Curr Allergy Asthma Rep. 2020;20(12).

Hidayani WR. Faktor Faktor Risiko Yang Berhubungan Dengan COVID 19?: Literature Review | Hidayani | Jurnal Untuk Masyarakat Sehat (JUKMAS). J Untuk Masy Sehat. 2020;4(2):125–6.

Wehling E, Nordin S, Espeseth T, Reinvang I, Lundervold AJ. Unawareness of olfactory dysfunction and its association with cognitive functioning in middle aged and old adults. Arch Clin Neuropsychol. 2011;26(3):264–6.

Husain Q, Kokinakos K, Kuo YH, Zaidi F, Houston S, Shargorodsky J. Characteristics of COVID-19 smell and taste dysfunction in hospitalized patients. Am J Otolaryngol - Head Neck Med Surg. 2021;42(6):2–4.

Alcas O, Saldaña D, Triveño A, Salazar M, Mejía P. Association between olfactory dysfunction and COVID-19 severity: A prospective study in a highly complex hospital in Peru. Ear Nose Throat J. 2021;0(0):3–7.

Moein ST, Hashemian SMR, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020;10(8):946–9.

D’Ascanio L, Pandolfini M, Cingolani C, Latini G, Gradoni P, Capalbo M, et al. Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell. Otolaryngol Head Neck Surg (United States). 2021;164(1):2–4.

Li JH, Sun Y, Li MR, Yuan H, Yang CL, Huang CC, et al. A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China. Mil Med Res. 2021;8(51):1–3.

Bhatia K, Zimmerman MA, Sullivan JC. Sex differences in angiotensin-converting enzyme modulation of ang (1-7) levels in normotensive WKY rats. Am J Hypertens. 2013;26(5):593–6.

Benkirane H, Heikel J, Laamiri FZ, Bouziani A, Lahmam H, Al-Jawaldeh A, et al. Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction. Front physiol. 2020;11:7–9.

Pourbagheri-Sigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in COVID-19 diagnosis and prognosis. Clin Chim Acta. 2020;510:477–80.

Yamada S, Asakura H. Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination. Int J Mol Sci. 2022;23(6):3–4.

Talavera B, García-azorín D, Martínez-pías E, Trigo J, Hernández-pérez I, Valle-peñacoba G, et al. Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci. 2020;419:5–6.

Downloads

Published

2023-12-26

How to Cite

Khotimah, R., Rahman, S., & Tofrizal, . T. (2023). Profil Pasien COVID-19 dengan Gangguan Penghidu di RSUP Dr. M. Djamil Padang Periode 1 Januari - 31 Desember 2021. Jurnal Otorinolaringologi Kepala Dan Leher Indonesia, 2(1). https://doi.org/10.25077/jokli.v2i1.40

Issue

Section

Penelitian